Nogal (Fluconazole) acts by inhibiting the synthesis of ergosterol, a major component of the cell membrane of yeast and fungi. Fluconazole is normally administered orally. Following oral administration, absorption is rapid and extensive, with > 90% of the dose being absorbed. Bioavailability is the same in fasting and fed states. The bioavailability of Fluconazole is unaffected by gastric pH. The plasma half-life is approximately 30 hrs. The plasma protein binding of Fluconazole is low, at 11% and the drug is widely distributed throughout the body. Most of the dose of Fluconazole is excreted unchanged in the urine, the remainder of the dose being eliminated in the urine as metabolites.

Nogal (Fluconazole) is indicated in the treatment of acute or recurrent vaginal candidiasis, mucosal candidiasis (as oropharyngeal candidiasis, oesophagitis, candiduria), systemic candidiasis and cryptococcal infections (including meningitis).

Vaginal candidiasis: The recommended dosage of Nogal for vaginal candidiasis is 150 mg as a single oral dose.
Oropharyngeal candidiasis: The recommended doses of Nogal for Oropharyngeal candidiasis is 200mg on the first day followed by 100mg once daily for 14 days
Esophageal Candidiasis: The recommended doses of Nogal for Esophageal Candidiasis 200mg on the first day followed by 100mg once daily. Doses up to 400mg/day may be used for 14 days
Systemic candida infection: 400 mg daily
Urinary tract Infection: For the treatment of Candida and urinary tract infections and peritonitis 50 mg to 200mg is used.

Nausea, abdominal discomfort, diarrhoea and flatulence, occasionally abnormalities of liver enzyme, rarely rash, angioedema and anaphylaxis reported.

Caution should be taken in renal impairment, pregnancy and breast-feeding and in raised liver enzyme. The use of Fluconazole in children below the age of one year is not recommended.

Nogal (Fluconazole) is contraindicated to patients hypersensitive to any component of this drug. It is also contraindicated in advanced liver disease.

Rifampicin reduces plasma concentration of Fluconazole. Effect of warfarin is enhanced. Plasma concentrations of sulphonylureas and theophylline are possibly increased. Effect of phenytoin is enhanced.

Store in a cool and dry place at a temperature below 30°C, keep away from sunlight. Keep out of the reach of children.