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Manlee

Generic Name: Tadalafil

Therapeutic Class: Drugs for Erectile Dysfunction


Dosage Form: Tablet


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Manlee

Description

When sexual stimulation causes the local release of nitric oxide in the corpus cavernosum, then nitric oxide activates the enzyme guanylyl cyclase, which results in increased levels of cGMP. The increased levels of cGMP in the corpus cavernosum produce smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. PDE5 degrades cGMP in the corpus cavernosum, and the inhibition of PDE5 by Tadalafil maintains increased levels of cGMP in the corpus cavernosum. Tadalafil has no effect on penile blood flow in absence of sexual stimulation.

Manlee

Indication

. Manlee is indicated for the treatment of erectile dysfunction (ED)
. Manlee  is indicated for the treatment of the signs & symptoms of benign prostatic hyperplasia (BPH)
. Manlee is indicated for the treatment of erectile dysfunction and the signs of benign prostatic hyperplasia (ED/BPH).

Manlee

Dosage & Administration

Erectile Dysfunction:For Use as Needed
• The recommended starting dose of Tadalafil for use as needed in most patients is10 mg, taken prior to anticipated sexual activity.
•  The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.For Once Daily Use:
•  The recommended starting dose of Tadalafil for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
 •  The Tadalafil dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.
Patients with BPH or with ED and BPH:Tadalafil for once daily use for BPHThe recommended dose of manlee for once daily  use is 5 mg, taken at approximately the same time every day.
Tadalafil for once daily use for ED and BPH:The recommended dose of Intimate for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.No dose adjustment is required in patients >65 years of age.

Manlee

Side Effect

Body as a whole: hypersensitivity reactions including rash, urticaria, facial edema, Stevens Johnson syndrome and exfoliative dermatitis.Cardiovascular and cerebrovascular: Serious cardiovascular events, including myocardial infarction, sudden cardiac death, unstable angina pectoris, ventricular arrhythmia, stroke, transient ischemic attacks, chest pain, palpitations, and tachycardia may occur. Skin and subcutaneous tissues:  hyperhidrosis (sweating).Gastrointestinal:  abdominal pain and gastroesophageal reflux.Nervous system:  migraine, transient global amnesia.Respiratory system:  epistaxis (nose bleed).

Manlee

Precautions

Cardiovascular:Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.Potential for Drug Interactions When Taking Manlee for Once Daily Use. Physicians should be aware that Manlee for once daily use provides continuous plasma tadalafil levels and should consider this when evaluating the potential for interactions with medications (e.g., nitrates, alpha-blockers, anti-hypertensives and potent inhibitors of CYP3A4).Prolonged Erection:There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds. Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Patients who have an erection lasting greater than 4 hours, whether painful or not, should seek emergency medical attention.  Manlee should be used with caution in patients who have conditions that might predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia), or in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie’s disease).Alpha blockers and Antihypertensives:Physicians should discuss with patients the potential for Manlee to augment the blood pressure lowering effect of alpha blockers and antihypertensive medications. Caution is advised when PDE5 inhibitors are coadministered with alpha blockers.

Manlee

Contraindications

Nitrates: Administration of tadalafil to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, Tadalafil is contraindicated in patients with a known serious hypersensitivity to tadalafil.

Manlee

Drug Interaction

Manlee

Storage

Store below 30° C. Protect from light and moisture. Keep out of reach of children.

Manlee