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Thiza

Generic Name: Azithromycin

Therapeutic Class: ANTIBIOTICS


Dosage Form: Tablet, PFS


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Thiza

Description

Thiza is an azalide antibiotic, a subclass of macrolide antibiotic. It acts by binding with the 50’S ribosomal subunit of Bacterial cell and blocks the protein synthesis of susceptible bacteria.

Thiza

Indication

Thiza is indicated for infection caused by susceptible organism in

* Upper respiratory tract infection including sinusitis, pharyngitis and tonsillitis

* Lower respiratory tract infection including bronchitis, acute exacerbation of chronic          obstructive pulmonary disease  (COPD), pneumonia

* Otitis media

 * Skin and soft tissue infection including cellulitis, pyoderma, erysipelas, wound infections.

 * Sexually transmitted diseases especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia tracomatis.

 * Genital ulcer diseases in men due to Hemophillus ducreyi

 * Mild or moderate typhoid due to multiple antibacterial resistant organisms.

Thiza

Dosage & Administration

Azithromycin tablet can be taken with or without food. Azithromycin suspension should be taken at least 1 hour before or 2 hours after meal.

Oral:

Adult:
For respiratory tract infections, otitis media and skin & soft tissue infections: 500 mg once daily for 3 days or an alternative to this as 500 mg once on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases like genital ulcer, non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis : a single 1 gm (1000 mg) dose. For the treatment of urethritis and cervicitis due to Neisseria gonorrhoeae : a single 2 gm (2000 mg) dose. In typhoid, 500 mg once daily for 7 days. In Cholera, a single 1 gm (1000 mg) dose. In Shigellosis, 500 mg once on day 1, followed by 250 mg once daily for next 4 days.

Thiza

Side Effect

Thiza is well tolerated with a low incidence of side effects. The side effects include nausea, vomiting, diarrhea, dizziness and skin rashes and reversible under discontinuation of therapy.

Thiza

Precautions

Caution should be taken as with any antibiotics observation for signs of super infection with non-susceptible organisms including fungi is recommended. Precaution should be taken in patients with severe renal diseases.

Thiza

Contraindications

Thiza is contraindicated in patients with hypersensitive to Azithromycin or other macrolide compound. Co-administration of ergot derivative and Azithromycin is contraindicated. Azithromycin is contraindicated in patients with liver diseases.

Thiza

Drug Interaction

Peak serum levels but not the total extent of absorption was reduced by the presence of Antacid. Azithromycin should be taken 1 hour before or 2 hour after this antacid. In patients receiving ergot alkaloids, Azithromycin should be avoided concurrently because of the possibility of ergotism.

Thiza

Storage

Thiza