Enzymatic debriding agents: Silver sulfadiazine may inactivate enzymatic debriding agents, thus the concomitant use of these compounds may be inappropriate. Oral hypoglycemic agents and phenytoin: In patients with large area burns where serum
sulfadiazine levels may approach therapeutic levels, the action of oral hypoglycemic agents and phenytoin may be potentiated and it is recommended that blood levels be monitored. Cimetidine: In-patients with large area burns, it has
been reported that co-administration of Cimetidine may increase the incidence of leukopenia.