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Fungimin Oral Gel

Generic Name: Miconazole BP

Therapeutic Class: ANTIFUNGAL


Dosage Form: Oral Gel


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Fungimin Oral Gel

Description

Fungimin oral gel is the preparation of Miconazole. It is a synthetic imidazole which exhibits broad spectrum activity against pathogenic dermatophytes, including Trichophyton species and yeasts including Candida species, Cryptococcus neoformans, Coccidioides immitis and Paracoccidioides brasiliensis as well as range of gram-positive cocci and bacilli. It acts by inhibiting membrane sterol synthesis and interfering with the permeability of the fungal cell membranes.

Fungimin Oral Gel

Indication

Fungimin Oral Gel is indicated to treat and prevent of fungal infections of the oropharynx (e.g. oral candidiasis in babies and oral candidiasis in other age groups),
gastrointestinal tract, nipple & breast of lactating mother and of super infections due to Gram-positive bacteria. Also indicated in prophylactic management of patients at high
risk from opportunistic fungal infection.

Fungimin Oral Gel

Dosage & Administration

For oral administration: Dosage is based on 15 mg/kg/day.
Infants under 2 years: Half tea-spoonful (2.5 ml) of gel twice daily.
Children aged 2-6 years: One tea-spoonful (5 ml) of gel twice daily.
Children aged 6 years and over: One teaspoonful (5 ml) of gel four times daily.
Adults: 1-2 tea-spoonfuls (5-10 ml) of gel four times daily.
For localized lesions of the mouth, a small amount of gel may be applied directly to the affected area with a clean finger, 2-4 times a day. For best results Fungimin ® Oral Gel should be kept in contact with the affected area as long as possible. Treatment should be continued for up to 2 days after the symptoms have cleared. For oral candidasis, dental prostheses should be removed at night and brushed with the gel. Elderly patients: Same as adult dose.

Fungimin Oral Gel

Side Effect

Occasionally, nausea and vomiting, diarrhoea with long term use, rarely allergic reactions, isolated reports of hepatitis.

Fungimin Oral Gel

Precautions

If the concomitant use of Miconazole and Anticoagulant is considered, the anti- coagulant effect should be monitored and titrated. Miconazole and Phenytoin level should also be monitored when used concomitantly. In infants and young children, caution must be taken to ensure that the gel does not obstruct the throat. Hence, the gel should not applied to the back of the throat and the full dose should be divided into smaller portions.

Fungimin Oral Gel

Contraindications

Miconazole is contraindicated in patients with known hypersensitivity to the active
ingredient.

Fungimin Oral Gel

Drug Interaction

Miconazole can inhibit the metabolism of drugs metabolized by the Cytochrome P450-3A and -2C9 families. Miconazole oral gel should not be used during treatment with cisapride, trizolam, oral midazolam, mizolastine, quinidine, simvastatin and lovastatin.

Fungimin Oral Gel

Storage

Store in a cool and dry place.

Fungimin Oral Gel