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Herculix

Generic Name: Ceftriaxone

Therapeutic Class: ANTIBIOTICS


Dosage Form: Injection


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Herculix

Description

Herculix is a sterile, semisynthetic, broad-spectrum, 3rd generation cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Ceftriaxone results from inhibition of cell wall synthesis. Ceftriaxone has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-negative and gram- positive bacteria.
Herculix 500 mg IM injection: Each vial contains Ceftriaxone 500 mg (as sterile Ceftriaxone Sodium USP) and each ampoule contains 2 ml Lidocaine HCl BP 1% injection.
Herculix 500 mg IV injection: Each vial contains Ceftriaxone 500 mg (as sterile Ceftriaxone Sodium USP) and each ampoule contains 5 ml water for injection BP.
Herculix 1 gm IM injection: Each vial contains Ceftriaxone 1 gm (as sterile Ceftriaxone Sodium USP) and each ampoule contains 3.5 ml Lidocaine HCl BP 1% Injection.
Herculix 1 gm IV injection: Each vial contains Ceftriaxone 1 gm (as sterile Ceftriaxone Sodium USP) and each ampoule contains 10 ml water for injection BP.
Herculix 2 gm IV injection: Each vial contains Ceftriaxone 2 gm (as sterile Ceftriaxone Sodium USP) and each of 2 ampoules contains 10 ml water for injection BP.

Herculix

Indication

Ceftriaxone is indicated for the treatment of the following major infections when caused by susceptible organisms: Renal and urinary tract infections, Lower respiratory tract infections, particularly pneumonia, Gonococcal infections, Skin and soft tissue infections, bone and joint infections, Bacterial meningitis, Serious bacterial infections e.g. septicemia, ENT infections, Infections in cancer patients, Prevention of postoperative infection, Perioperative prophylaxis of infections associated with surgery, Typhoid fever.

Herculix

Dosage & Administration

Ceftriaxone can be administered either intravenously or intramuscularly. When reconstituted for intramuscular or intravenous injection, the white to yellowish-orange crystalline powder gives a pale yellow to amber solution. Adults: The usual adult daily dose is 1-2 gm once daily, (or twice daily in equally divided doses) depending on the type and severity of infection. The daily dose may be increased, but should not exceed 4 gm. For preoperative use (surgical prophylaxis), a single dose of 1 gm administered intravenously 0.5-2 hours before surgery is recommended. In elderly patients, the dosages do not require modification provided that renal and hepatic functions are satisfactory. In patients with impaired renal function, there is no need to reduce the dosage of Ceftriaxone provided liver function is intact. In patients with liver damage, there is no need for the dosage to be reduced provided renal function is intact. Gonorrhea: For the treatment of gonorrhea (penicillinase producing and non-penicillinase producing strains), a single  intramuscular  dose  of 250  mg  is  recommended.  Children  under  12  years:  The recommended total daily dose is 50 to 75 mg/kg once daily (or twice daily in equally divided doses). In severe infections, up to 80 mg/kg body weight daily may be given. The total daily dose
should not exceed 2 gm. In the treatment of meningitis, the initial dose of 100 mg/kg body weight (not to exceed 4 gm daily) once daily (or twice daily in equally divided doses), is recommended. As soon as the causative organism has been identified and its sensitivity, the doses can be reduced accordingly. The usual duration of therapy in meningitis is 7 to 14 days.

Herculix

Side Effect

Ceftriaxone is generally well tolerated. A few side-effects such as 1. Gastrointestinal effects include diarrhea, nausea and vomiting, stomatitis and glossitis 2. Cutaneous reactions include rash, pruritus, urticaria, edema & erythema multiforme 3.Hematological reactions include eosinophilia, thrombocytosis, leukopenia, and neutropenia 4. Hepatic reactions include elevations of SGOT or SGPT, bilirubinemia 5. CNS reactions include headache, hyperactivity, nervousness, sleep disturbances, confusion, hypertonia, and dizziness were reported. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Herculix

Precautions

Ceftriaxone should be administered with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Herculix

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. It’s safety in human pregnancy has not been established. Ceftriaxone is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium.

Herculix

Drug Interaction

Potentially hazardous interactions: No impairment of renal function or increased nephrotoxicity has been observed in man after simultaneous administration of ceftriaxone with diuretics, or with aminoglycosides. A possible disulfiram-like reaction may occur with alcohol. Other significant interactions: Ceftriaxone doesn't interfere with the protein binding of bilirubin. Simultaneous administration of probenecid doesn't alter the elimination of ceftriaxone. Potentially useful interactions: Experimentally, in vivo, ceftriaxone has been shown to enhance bacterial killing by human neutrophils.

Herculix

Storage

Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately. Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).

Herculix