Ampre  Plus is a fixed dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium channel blocker with long duration of action that reduces hypertension inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Atenolol is a cardio-selective beta-blocker that causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS.

Ampre  Plus is used in hypertension not controlled by monotherapy, angina pectoris & hypertension as co-existing diseases, Post Myocardial Infarction, Refractory angina pectoris where nitrate therapy has failed.

The recommended dose of Ampre  Plus is one tablet daily. Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with ½ tablet of Ampre  Plus i.e. 2.5 mg of Amlodipine & 25 mg Atenolol.

Ampre  Plus, the combination of amlodipine and atenolol is well tolerated. Overall side effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.

Ampre  Plus should be used with caution in patients with airway obstruction. Ampre® Plus can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30ml/min because of possible reduction in the excretion of unchanged Atenolol. Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half life of Amlodipine. Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under regular observation.

Ampre  Plus is contraindicated in patients with hypersensitivity to any of the component of the products. Amlodipine should not be used in cardiogenic shock, aortic stenosis, and unstable angina. Atenolol should not be used in severe bradycardia, second or third degree of heart block, uncontrolled heart failure, hypotension, sick sinus syndrome and poor left ventricular function.

Amlodipine has no significant drug interaction. Atenolol reduces the clearance of disopyramide by 20%. Ampicillin at doses of 1g or above may reduce Atenolol levels. Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion in response to oral antidiabetics. The effect of Atenolol may be enhanced by adrenergic neuron blocking agents such as Guanethidine or Bethanidine.

Ampre  Plus should be stored at room temperature between 15-30  C away from light and moisture at cool and dry place. Keep all medicines away from children.