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Napium

Generic Name: Naproxen

Therapeutic Class: ANALGESIC,ANTIPYRETIC & NSAIDS


Dosage Form: Tablet


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Napium

Napium 250 tablet  Each enteric coated tablet contains Naproxen Sodium USP equivalent to Naproxen 250 mg.

Napium 500 tablet  Each enteric coated tablet contains Naproxen Sodium USP equivalent to Naproxen 500 mg.

Description

Napium is a Non-Steroidal Anti-inflammatory agent. The drug exhibits anti-inflammatory, analgesic, and antipyretic activity by inhibiting prostaglandin synthesis. Both Naproxen and Naproxen Sodium are completely absorbed from the GIT but the peak plasma concentration is attained about 1-2 hours after ingestion of Naproxen Sodium whereas that takes 2-4 hours after ingestion of Naproxen.

Napium

Indication

Naproxen is indicated for the relief of symptoms of rheumatoid arthritis, both of acute flares and long term management of the disease. It is also used in the diseases of rheumatoid osteoarthritis (degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid arthritis, tendinitis, brusitis, acute gout, acute musculoskeletal disorders (such as sprains, direct trauma and fibrositis), migraine and dysmenorrhoea.

Napium

Dosage & Administration

Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250 to 500 mg twice daily. May be increased to 1.50 gm for limiting periods. Morning and evening doses do not have to be equal, and use of the drug more frequently than twice daily is not necessary. Symptomatic arthritis improvement usually begins in 2 weeks, if no improvement is seen, consider a trial for 2 more weeks.

Mild to moderate pain, primary dysmenorrhoea, acute tendinitis, bursitis, and dysmenorrhoea: 500 mg initially, followed by 250 mg every 6 to 8 hours as required. Do not exceed a 1.375 gm total daily dose.

Acute gout: 750 mg, then 250 mg every 8 hours until attack subsides.

Juvenile arthritis (children over 5 years): 10 mg/kg daily in two divided doses is recommended.

Napium

Side Effect

Gastro-intestinal discomfort: Nausea, diarrhea and occasionally bleeding and ulceration. Hypersensitivity reactions: Notably with bronchospasm, rashes and angioedema.

CNS side effect Drowsiness, headache, fluid retention, vertigo, hearing disturbances such as tinnitus, photosensitivity.

A few instances of jaundice, impairment of renal function, thrombocytopenia, and agranulocytosis have been reported.

Napium

Precautions

Napium

Contraindications

Naproxen should be used with caution in patients with cardiac, hepatic and renal impairment, coagulation defect, and previous history of gastro-intestinal ulceration. The drug is contraindicated in patients with a history of hypersensitivity to aspirin or any other NSAID - which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAID.

Napium

Drug Interaction

Use in patients receiving ACE inhibitors may potentiate renal diseases. Drug which are Albumin-bound may be displaced from their binding sites as a result of the naproxen anions’ affinity for protein. Use with caution when given concomitantly with coumarin- type anticoagulants, hydantion sulfonamides, or sulfonylureas. Concomitant administration is not recommended because reduction in the antihypertensive effect of propranolol and other beta-blockers may occur. Concurrent administration of probenecid or methotrexate should be done cautiously to prevent potential naproxen and methotrexate toxicity, respectively.

Napium

Storage

Protect from light and store below 30 C temperature in a dry place.

Napium