Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250 to 500 mg twice daily. May be increased to 1.50 gm for limiting periods. Morning and evening doses do not have to be equal, and use of the drug more frequently than twice daily is not necessary. Symptomatic arthritis improvement usually begins in 2 weeks, if no improvement is seen, consider a trial for 2 more weeks.
Mild to moderate pain, primary dysmenorrhoea, acute tendinitis, bursitis, and dysmenorrhoea: 500 mg initially, followed by 250 mg every 6 to 8 hours as required. Do not exceed a 1.375 gm total daily dose.
Acute gout: 750 mg, then 250 mg every 8 hours until attack subsides.
Juvenile arthritis (children over 5 years): 10 mg/kg daily in two divided doses is recommended.