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Ximocef

Generic Name: Cefpodoxime

Therapeutic Class: ANTIBIOTICS


Dosage Form: Capsule, PFS


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Ximocef

Ximocef Capsule  Each box contains 2 Alu-Alu blister strips of 4 capsule.

Ximocef 100 Suspension  Box containing dry powder to reconstitute 50 ml suspension.

Ximocef 40 Suspension  Box containing dry powder to reconstitute 50 ml suspension.

Description

Cefpodoxime Proxetil is a beta-lactum antibiotic, a 3rd generation oral cephalosporin. It Is the prodrug of Cefpodoxime. It Is aclive against both Gram-positive and Graim-negative bacteria. It is taken up in the intestine and is hydrolyzed ID active metabolite Cefpodoxime. The volume of dlstrtbution Is 32.3 L & peak plasma levels of Cefpodoxime occur 2 to 3 hours after dosing. Serum protein binding of Cefpodoxime is 40% principally lo albumin. The main route of excretion is renal, 80% is excreted unchanged in the urine with an elimination half-life of approximately 2.4 hours.

Ximocef

Indication

Ximocef (Cefpodoxime) is indiceled for the treatment of­-
Upper and lower 111Spiratory llact inflictions Upper and lower u nary lract Infections
Gonococcal infection
Skin and soft assue Infections

Ximocef

Dosage & Administration

Ximocef suspension may be given without regard to food. The recommended doses, duration of
treatment, applicable patient
population ara as below:

Ximocef

Side Effect

Cefpodoxime Proxetil has very few side etrects. The side atrects include diarrhea, nausea, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children, fungal slcin rash is more than adults.

Ximocef

Precautions

Ximocef

Contraindications

Ximocef

Drug Interaction

Antacids: Concomitant administration of high doses of antacids (sodium bica nate and aluminium
hydroxide) or H2 blockers reduce peak plasma level by 24% to 42% and the extent of abso on by 27% to 32% respectively.
Probenecid: Ranaf excretion of cefpod ima was inhibiled by probenecid and resulted in an
approximataly 31% increase in AUC.
Nephrotoxic drugs: Clcsa monitoring of renal function is advised when Cefpodcxime Proxatil is
administarad concomftanlly with compounds of known nephrotoxic potential.

Ximocef

Storage

Ximocef