The usual starting dose of Loepre is 50 mg once daily, with 25 mg used in patients with
possible depletion of intravascular volume (e.g. patients treated with diuretics) and patients with
a history of hepatic impairment. Loepre can be administrated once or twice daily doses ranging from 25 to 100 mg. If the antihypertensive effect measured at trough using once daily dosing is inadequate, a twice daily regimen at the same total daily dose or an increase in dose may give a more satisfactory response. If blood pressure is not controlled by Lospe alone, a low dose of a diuretic may be added. No initial dosage adjustment is necessary for elderly patients with renal impairment, including patients on dialysiis; Lospre may be administered with or without food.