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Diazox

Generic Name: Nitazoxanide

Therapeutic Class: ANTHELMINTIC


Dosage Form: Tablet Suspension


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Diazox

Diazox 500mg Tablet  Each film coated tablet contains Nitazoxanide INN 500 mg.

Diazox 30ml PFS  Each 5 ml suspension contains Nitazoxanide INN 100 mg.

Description

Nitazoxanide, a synthetic antiprotozoal agent. Nitazoxanide is well absorbed from GIT. It interferes with the Pyruvate Ferredoxin Oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic glucose energy metabolism. This results in cell swelling, membrane damage resulting in dysfunction of the parasite.

Diazox

Indication

Diazox (Nitazoxanide), is indicated for the treatment of
1. Diarrhoea caused by Cryptosporidium parvum and Giardia lamblia.
2. Amebiasis and helminth infections.

Diazox

Dosage & Administration

Age 1 - 3 years : 5 ml (100 mg) twice daily for 3 days
Age 4 - 11 years: 10 ml (200 mg) twice daily for 3 days
Age >12 years : 25 ml or 1 tablet (500 mg) twice daily for 3 days
The suspension or tablet should be taken with food.

Diazox

Side Effect

Diazox (Nitazoxanide) is generally well tolerated. However abdominal pain, diarrhoea vomiting and headache have been reported rarely.

Diazox

Precautions

The pharmacokinetics of Diazox (Nitazoxanide) in patients with compromised renal or hepatic function have not been studied. Therefore, nitazoxanide must be administered with caution to patients with hepatic and biliary disease, to patients with renal disease and to patients with combined renal and hepatic disease.

Diazox

Contraindications

Diazox (Nitazoxanide) is contraindicated in patients with a prior hypersensitivity to nitazoxanide or any other ingredient in the formulations.

Diazox

Drug Interaction

Diazox (Nitazoxanide) is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin).

Diazox

Storage

Store in a cool and dry place, away from light and moisture. Store the tablets, unsuspended powder, and the reconstituted oral suspension at 25°C. Once reconstituted suspension should be used within 7 days.

Diazox