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Generic Name: Ketorolac Tromethamine


Dosage Form: Tablet

View Prescribing

  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage



Doloket 10mg Tablet  Each film coated tablet contains Ketorolac Tromethamine USP 10 mg.


Doloket (Ketorolac Tromethamine) is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that is used short-term (7 days or less) to treat moderate to severe pain, usually pain that occurs after an operation or other painful procedure.



Doloket is indicated for the short-term management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting.


Dosage & Administration

Doloket tablets are recommended for short-term use only (up to 7 days) and are not recommended for chronic use. 10 mg every 4 to 6 hours as required. Doses exceeding 40 mg per day are not recommended. For patients receiving parenteral Ketorolac Tromethamine, and who are converted to Ketorolac Tromethamine oral tablets, the total combined daily dose should not exceed 90 mg (60 mg for the elderly, renally impaired patients and patients less than 50 kg) and the oral component should not exceed 40 mg on the day the change of formulation is made.


Side Effect

Most commonly- reported side effects of Doloket are, gastrointestinal symptoms with dyspepsia, gastrointestinal pain, nausea, and vomiting occurring in 3-9% of patients. Such symptoms probably necessitate discontinuation of the drug as they may herald more serious pathology.



Patients over the age of 65 years may be at a greater risk of experiencing adverse effects than younger patients after using of Doloket. Doloket can cause gastro-intestinal irritation, ulcers or bleeding in patients with or without a history of previous symptoms. Bronchospasm may be precipitated in patients with a history of asthma. Since ketorolac tromethamine and its metabolites are excreted primarily by the kidney, patients with moderate to severe impairment of renal function (serum creatinine greater than 160 micromole/L) should not receive. Fluid retention and edema have been reported with the use of Ketorolac tromethamine.



Ketorolac Tromethamine is contraindicated in patients having hypersensitivity to this drug or other NSAIDs and those patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions. It is also contraindicatad in a history of peptic ulcer, gastro-intestinal bleeding, severe renal impairment or history of asthma. Ketorolac tromethamine is contra­indicated as prophylactic analgesia before surgery due to inhibition of platelet aggregation and is contra-indicated intra operatively because of the increased risk of bleeding. It is also contraindicated  during pregnancy, labor or lactation.


Drug Interaction

Ketorolac Tromethamine should not be used with other NSAIDs or in patients receiving aspirin because of the potential for additive side-effects. Care should be taken when administering Ketorolac Tromethamine with anti-coagulants since co-administration may cause an enhanced anti-coagulant effect. Ketorolac Tromethamine and other non-steroidal anti-inflammatory drugs can reduce the anti-hypertensive effect of beta-blockers and may increase the risk of renal impairment when administered concurrently with ACE inhibitors, particularly in volume depleted patients. Caution is advised when methotrexate is administered concurrently, since some prostaglandin synthesis inhibiting drugs have been reported to reduce the clearance of methotrexate, and thus possibly enhance its toxicity. Probenecid should not be administered concurrently with Ketorolac Tromethamine because of increases in ketorolac plasma level and half-life.



Store Doloket in a cool and dry place away from light. Keep out of reach of children.