Cefadyl
Generic Name: Cefixime
Therapeutic Class: ANTIBIOTICS
- Presentation
- Description
- Indications
- Dosage & Administration
- Side Effect
- Precautions
- Contraindications
- Drug Interaction
- Storage
Presentation
Cefadyl 200 Capsule Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.
Cefadyl 400 Capsule Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 400 mg.
Paediatric Drops Each ml reconstituted suspension contains Cefixime Trihydrate USP 27.98 mg. equivalent to Cefixime 25 mg.
Cefadyl Powder for Suspension After reconstitution according to direction, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 100 mg.
Description
Cefixime is a semi-synthetic, broad spectrum cephalosporin antibiotic for third generation for oral administration. It is a bactericidal antibiotic, kills bacteria by interfering in the synthesis of the bacterial cell wall. Cefixime is highly stable in the presence of beta-lactamase enzymes. Cefixime has marked in-vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms including beta-lactamase producers.
Clinical efficacy of Cefixime has been demonstrated in infections caused by commonly occurring pathogens including Gram-positive organism Streptococcus pneumonia, Streptococcus pyogenes, Gram-negative organisms Escherichia coli, Proteus nirabilis, Klebsiella spp., Haemophilus influenza(beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), Salmonella typhi and Enterobacter species.
Indication
Cefadyl is indicated in the following infectious diseases –
Respiratory Tract Infections:
Pneumonia
Sinusitis
Pharyngitis and Tonsillitis
Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis (AECB)
Otitis Media
Typhoid
Urinary Tract Infections
Uncomplicated gonorrhea (cervical/urethral)
Dosage & Administration
| Age | Cefadyl Capsule |
|---|---|
| Adult and child over 10 years | 200 or 400 mg daily as a single dose or in two divided doses |
| Cefadyl Suspension / Paediatric Drops | |
| Child over 6 months | 8 mg/kg daily as a single doea or in 2 divided dosses |
| Child 6 months - 1 year | 3.75 ml or 75mg daily |
| 1-4 years | 5 ml or 100 mg daily |
| 4-10 years | 10 ml or 200 mg daily |
| 10-12 years | 15 ml or 300 mg daily |
| Above 12 years | 15 ml or 20 ml or 200-400 mg daily |
Side Effect
Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials are mild and self-limiting in nature.
Gastro-intestinal disturbance: Diarrhea (if severe diarrhea occurs, Cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting and flatulence have been reported.
CNS disturbances: Headache, dizziness.
Others: Hypersensitivity reactions which usually subside upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.
Precautions
Cefixime should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance < 20 ml/min).
Contraindications
Patients with known hypersensitivity to Cefixime or cephalosporin group of drugs.
Drug Interaction
Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when Cefixime is administered concomitantantly.
Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.
Warfarin and Anticoagulants: Increased prothombin time, with or without clinical bleeding, has been reported when Cefixime is administered concomitantly.
Storage