Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials are mild and self-limiting in nature.
Gastro-intestinal disturbance: Diarrhea (if severe diarrhea occurs, Cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting and flatulence have been reported.
CNS disturbances: Headache, dizziness.
Others: Hypersensitivity reactions which usually subside upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.