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Cefadyl

Generic Name: Cefixime

Therapeutic Class: ANTIBIOTICS


Dosage Form: Capsule, PFS


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Cefadyl

Cefadyl 200 Capsule  Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.

Cefadyl 400 Capsule  Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 400 mg.

Paediatric Drops  Each ml reconstituted suspension contains Cefixime Trihydrate USP 27.98 mg. equivalent to Cefixime 25 mg.

Cefadyl Powder for Suspension  After reconstitution according to direction, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 100 mg.

Description

Cefixime is a semi-synthetic, broad spectrum cephalosporin antibiotic for third generation for oral administration. It is a bactericidal antibiotic, kills bacteria by interfering in the synthesis of the bacterial cell wall. Cefixime is highly stable in the presence of beta-lactamase enzymes. Cefixime has marked in-vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms including beta-lactamase producers.

Clinical efficacy of Cefixime has been demonstrated in infections caused by commonly occurring pathogens including Gram-positive organism Streptococcus pneumonia, Streptococcus pyogenes, Gram-negative organisms Escherichia coli, Proteus nirabilis, Klebsiella spp., Haemophilus influenza(beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), Salmonella typhi and Enterobacter species.

Cefadyl

Indication

Cefadyl is indicated in the following infectious diseases –

                Respiratory Tract Infections:

                Pneumonia

                Sinusitis

                Pharyngitis and Tonsillitis

                Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis (AECB)

                Otitis Media

                Typhoid

                Urinary Tract Infections

                Uncomplicated gonorrhea (cervical/urethral)

Cefadyl

Dosage & Administration

Age Cefadyl Capsule
Adult and child over 10 years 200 or 400 mg daily as a single dose or in two divided doses
  Cefadyl Suspension / Paediatric Drops
Child over 6 months 8 mg/kg daily as a single doea or in 2 divided dosses
Child 6 months - 1 year 3.75 ml or 75mg daily
1-4 years 5 ml or 100 mg daily
4-10 years 10 ml or 200 mg daily
10-12 years 15 ml or 300 mg daily
Above 12 years 15 ml or 20 ml or 200-400 mg daily

Cefadyl

Side Effect

Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials are mild and self-limiting in nature.

Gastro-intestinal disturbance: Diarrhea (if severe diarrhea occurs, Cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting and flatulence have been reported.

CNS disturbances: Headache, dizziness.

Others: Hypersensitivity reactions which usually subside upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.

Cefadyl

Precautions

Cefixime should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance < 20 ml/min).

Cefadyl

Contraindications

Patients with known hypersensitivity  to Cefixime or cephalosporin group of drugs.

Cefadyl

Drug Interaction

Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when Cefixime is administered concomitantantly.

Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

Warfarin and Anticoagulants: Increased prothombin time, with or without clinical bleeding, has been reported when Cefixime is administered concomitantly.

Cefadyl

Storage

Cefadyl