Ampre is a dihydropyridine calcium channel blocker with long duration of action that reduces hypertension inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.

Ampre is slowly and incompletely absorbed, with 60-80% of an oral dose reaching the systemic circulation. Plasma half life of Ampre ranges from 30-60 hrs (mean 35.7 hrs). Ampre  is extensively metabolized in the liver prior to excretion with only about 5% unchanged drug excreted in the urine.

Ampre  is indicated for the first line treatment of hypertension. Ampre  is also indicated for the treatment of stable angina and vasospastic angina. It may be used alone or in combination with other antihypertensive agents or antianginal drugs.

For the treatment of both hypertension and angina the usual initial dose is 5 mg once daily. If the desired therapeutic effect can not be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Dosage should be adjusted according to each patient's need. Elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily dose and this dose may be used when adding Ampre  to other antihypertensive therapy.

Ampre  is generally well tolerated. Headache, oedema, fatigue, nausea, flushing, dizziness, gum hyperplasia; erythema are most commonly reported side effects.

Ampre  should be used with caution in patients with heart failure, renal failure and hepatic failure. Ampre  is not a beta-blocker and therefore gives no protection against the danger of abrupt beta-blocker withdrawal; any such withdrawal should be gradual reduction of the dose of beta-blocker.

Ampre   is contraindicated in patients with known hypersensitivity to dihydropyridine (e.g. amlodipine, nifedipine, nicardipine, isradipine).

Ampre  may enhance the effect of other antihypertensive (e.g. Beta-blocker, ACE inhibitors, Alpha-1-blockers and Diuretics). In clinical study amlodipine did not affect the pharmacokinetics of Atorvastatin, Digoxin Warfarin Cimetidine. Food does not alter the rate or extent of absorption of amlodipine.

Ampre   should be stored at room temperature between 15-30  C away from light and moisture at cool and dry place. Keep all medicines away from children.