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Amboxol

Generic Name: Ambroxol

Therapeutic Class: ANTI-HISTAMINES & RESPIRATORY


Dosage Form: Capsule


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Amboxol

Amboxol 100ml Syrup  Each 5ml of syrup contains 15 mg Ambroxol hydrochloride BP.

Amboxol Paediatric Drops  Each ml of drop contains 6 mg Ambroxol hydrochloride BP.

Description

Ambroxol is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. Ambroxol is the active metabolite of bromhexine and this metabolite possesses a greater bronchosecretolytic effect than bromhexine.

Ambroxol improves sputum rheology by hydrating mechanism leading to liquefication of mucus in the lumen of respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Ambroxol has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.

Amboxol

Indication

Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, Inflammatory disease of rhinopharyngeal tract (laryngitis, Pharyngitis, sinusitis and rhinitis) associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick  expectoration, Bronchiectasis, Chronic pneumonia

Amboxol

Dosage & Administration


Average daily dose (preferably after meal):

Amboxol syrup:

                2 - 5 years old : 2.5 ml (1/2 teaspoonful), 2-3 times a day

                5 – 10 years old : 5 ml (1 teaspoonful), 2-3 times a day

                10 years and adults : 10 ml (2 teaspoonful) 3 times a day

Amboxol Paediatric Drops:

                0 - 6 months old : 0.5 ml, 2 times a day

                6 - 12 months old : 1 ml, 2 times a day

1 - 2 years old : 1.25 ml, 2 times a day

Amboxol

Side Effect

Gastrointestinal side effects like epigastric pain, stomach overfills feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema has been reported.

Amboxol

Precautions

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Amboxol

Contraindications

Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

Amboxol

Drug Interaction

Amboxol should not be taken simultaneously with antitussives (e.g. Codeine) because phlegm, which has been liquefied by Ambroxol might not be expectorated.

Amboxol

Storage

Protect from direct light exposure. Store in dry place at a temperature not exceeding 30 C. Keep out of the reach of children.

Amboxol