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Thiza

Generic Name: Azithromycin

Therapeutic Class: ANTIBIOTICS


Dosage Form: Tablet, PFS


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Thiza

Description

Thiza (Azithromycin) is an azalide antibiotic, subclass of the macrolideclass of antibiotics.Thiza (Azithromycin) acts by binding to the 50s ribosomal subunit of susceptible organisms and thus interferes with microbial protein synthesis. Thiza (Azithromycin) demonstrated activity in vitro, against a wide range of gram-positive and gram-negative bacteria including: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (Group A) and other Streptococcal species ; Haemophilus influenza and parainfluenzae; Moraxella catarrhalis; anaerobes including Bacteroides fragilis, Escherichiacoli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, Neisseria gonorrhoeae and Chlamydia trachomatis. Thiza (Azithromycin) also demonstrates activity in vitro against Legionella pneumophila, Mycoplasma pneumonia and hominis; Campylobacter spp.,Toxoplasma gondii and Treponema pallidum.

Thiza

Indication

Thiza is indicated for infection caused by susceptible organism in

Upper respiratory tract infection including sinusitis, pharyngitis and tonsillitis

Lower respiratory tract infection including bronchitis, acute exacerbation of chronic obstructive pulmonary disease (COPD), pneumonia

Otitis media

Skin and soft tissue infection including cellulitis, pyoderma, erysipelas, wound infections.

Sexually transmitted diseases especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia tracomatis.

Genital ulcer diseases in men due to Hemophillus ducreyi

Mild or moderate typhoid due to multiple antibacterial resistant organisms.

Thiza

Dosage & Administration

Thiza Tablet and suspension should be taken at least 1 hour before or 2 hour after meal. However, 500 tablet can be taken with or without food. To reconstitute Thiza suspension, add 10 ml or 2 spoonfuls of just boiled and cooled water to the content of the bottle and shake well to mix uniformly. Adults: For lower respiratory tract infections including bronchitis and pneumonia, upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, otitis media and skin and soft tissue infections, the total dose of Thiza is 1.5 gm given as 500 mg once daily for 3 days. An alternative to this dosage schedule is that 500 mg once daily on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis, the dose of Thiza is 1 gm given as a single dose. Alternatively, 500 mg once daily on day 1, followed by 250 mg once daily for next 2 days may also be given. Use in the elderly: Normal adult dosage is recommended. Children: The dose of Thiza in children over 6 months of age is 10 mg/kg body weight once daily for 3 days. Alternatively, 10 mg/kg on day 1, followed by 5 mg/kg for next 4 days is also recommended. There is no information on use of Azithromycin on children under 6 months of age. For children with body weight 15-25 kg (3-7 years), the dose is 200 mg once daily for 3 days; for body weight 26-35 kg (8-11 years), the dose is 300 mg once daily for 3 days; for body weight 36-45 kg (12-14 years), the dose is 400 mg once daily for 3 days. For body weights over 45 kg, normal adult dosage is recommended

Thiza

Side Effect

Common side effects: Azithromycin is well tolerated with a low incidence of side effects. The side effects include nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhoea, headache, dizziness and skin rashes and are reversible upon discontinuation of therapy.

Rare side effects: Relevant data is not available

Thiza

Precautions

Caution should be taken as with any antibiotics observation for signs of super infection with non-susceptible organisms including fungi is recommended. Precaution should be taken in patients with severe renal diseases.

Thiza

Contraindications

Thiza is contraindicated in patients with hypersensitive to Azithromycin or other macrolide compound. Co-administration of ergot derivative and Azithromycin is contraindicated. Azithromycin is contraindicated in patients with liver diseases.

Thiza

Drug Interaction

With Medicine: Antacids: Peak serum levels but not the total extent of absorption are reduced by Aluminium and Magnesium containing antacids in the stomach. Azithromycin should therefore be taken at least 1 hour before or 2 hours after taking these antacids.  Ergot Derivatives: Because of the theoretical possibility of ergotism, concomitant administration of ergot derivatives and Azithromycin should be avoided. Digoxin & Cyclosporin: Macrolides have been known to increase the plasma concentration of Digoxin & Cyclosporin and so caution should be exercised while co-administration is necessary. Antihistamines: A potentially life threatening interaction between erythromycin and terfenadine or Astemizole have been reported.  Although such an interaction with azithromycin is not established yet, it is wise to avoid concomitant use of Azithromycin and Terfenadine or Astemizole.

With Food & others: Relevant data is not available

Thiza

Storage

Store in a cool and dry place, below 30  C, away from light

Thiza