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Urilizer

Generic Name: Potassium Citrate & Citric Acid Monohydrate

Therapeutic Class: Urinary alkalinizing agent & prevention of repeated kidney stone formation


Dosage Form: Oral Solution


View Prescribing


  • Presentation
  • Description
  • Indications
  • Dosage & Administration
  • Side Effect
  • Precautions
  • Contraindications
  • Drug Interaction
  • Storage

Presentation

Urilizer

Description

Urilizer is a combined preparation of Potassium Citrate & Citric Acid Monohydrate. Potassium Citrate is absorbed and metabolized to Potassium Bicarbonate, thus acting as a systemic alkalinizer. The effects are essentially those of chlorides before absorption and those of bicarbonates subsequently. Oxidation is virtually complete so that less than 5% of the Potassium Citrate is excreted in the urine unchanged. It alkalinizes the urine without producing a systemic alkalosis in recommended dosage.

Urilizer

Indication

Urilizer is indicated in following cases:

To  relieve  discomfort  in  urinary  tract  infections  due  to decreased pH or acidic urine.

 In preventing kidney stone formation specially caused by uric acid with or without the presence of calcium stones.

 In gout therapy  as a valuable adjuvant with uricosuric agents. Also effective in correcting acidosis caused by kidney disease.

Urilizer

Dosage & Administration

Urilizer Oral Solution should be taken diluted in water according to directions, followed by additional water, if desired. Palatability is enhanced if chilled before taking. Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations.

To relieve discomfort in UTI:

Adults and children over 6 years: 10 ml 3 times daily, diluted with 1 glass of water.

Children 1-6 years: 5 ml 3 times daily, diluted with ½ glass of water.

To prevent kidney stones & acidosis caused by kidney diseases: Adults: 10-15 ml 4 times daily (or as directed by the physician) diluted with 1 glass of water.

Children: 5-10 ml 4 times daily (or as directed by the physician) diluted with ½ glass of water.

 In gout therapy (with uricosuric agent):

Adults: 10-15 ml 4 times daily (or as directed by the physician), diluted with 1 glass of water.

Children: 5-10 ml 4 times daily (or as directed by the physician), diluted with ½ glass of water.

Urilizer

Side Effect

Urilizer oral solution is generally well tolerated without any side effects when given in recommended doses to patients with normal renal function and urinary output.

Urilizer

Precautions

Large doses may cause hyperkalemia & alkalosis, especially in the presence of renal disease. Do not exceed recommended dosage. Discontinue use if adverse reaction occurs. Should be used with caution by patients with low urinary output unless under the supervision of a physician. As with all liquids containing a high concentration of potassium, patients should be directed to dilute adequately   with   water   to   minimize   the   possibility   of gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations; and preferable, to take each dose after meals to avoid saline laxative effect.

Urilizer

Contraindications

Severe renal impairment with oliguria or azotemia, untreated Addison's disease, adynamia   episodica hereditaria, acute dehydration, heat cramps, anuria, severe myocardial damage, and

hyperkalemia from any cause. Known hypersensitivity to any ingredient.

Urilizer

Drug Interaction

Some products that may interact with this drug include: antacids that contain aluminum, aspirin and other salicylates (e.g., salsalate), certain blood pressure medications (e.g., ACE inhibitors such as lisinopril, angiotensin blockers such as losartan), drospirenone, eplerenone, certain heart medications (e.g., quinidine, digoxin), lithium,   potassium   supplements,   certain   "water   pills" (potassium-sparing diuretics such as amiloride, spironolactone, triamterene).

 

Urilizer

Storage

Store in a dry place protected from light. Keep out of the reach of children.

Urilizer